3425 Effect of the topical administration of diclofenac sodium and indomethacin on corneal sensitivity in normal subjects

pumose To compare the efficacy of topical indomethicin, dicMenac and ketorolac as pain relief following excimer laser P.R.K. &&Q&s Double masked, random&d trial involving 360 patients. Au patients rece.ived a standard regime of one of the trial dmgs and chloramphenicol ointment to be used four times daily for 3 days. Pain levels were assessed on B I ocm linear aMlogue scale prior to each instillation of the topical medication. Patients were advised to use. paracetamol as additional pain relief but were allowed to use any oral analgesia ( except non-steroidal agents ) which they documented ( type and quantity ). Qmlity of sleep was graded. A comparison of end r&action and haze levels is made. &&g ‘Ihere was no significant diffe.re.nce in pain scores between the groups using diclofenso and k&xc&. Ketorolac was signiticantly better than indomethicin for pain relief at hours I8 and 60 ( p<O.Ol ); while diclofenac was signi&mtly better than indometbicin at hour 18 ( p<O.Ol ). COnClUSiOU In this tidy, there is no significant di&rence between topical ketorolac and diclofenac as pain relief following mimer laser PRK. Both of these drugs are signiticantly better than topical indonwtbicia